#Actimeter tremor index registration

This increase in AP2 was stronger than enhancement of locomotor activity induced by apomorphine in the harmaline-treated animals. Apomorphine administered at the doses of 0.5 and 1mg/kg sc further enhanced AP2 and at the lower dose also the tremor index elevated by harmaline. Propranolol injected at a dose of 20mg/kg ip reversed both of these effects of harmaline. RESULTS: The tremor induced by harmaline administered at a dose of 15 mg/kg ip was associated with an increase in power in the 9-15 Hz band (AP2) and in the tremor index, calculated as a difference between AP2 and power in the 0-8 Hz band (AP1). Tremor was analyzed using a Fourier transform to generate power spectra for rhythmic behavior. METHODS: Tremor, locomotor activity and focused stereotypy were measured objectively using force plate actimeters. Propranolol (a first-line drug in essential tremor) was used as a reference compound. The aim of the present study was to examine the influence of apomorphine, a non-selective dopamine receptor agonist, on the tremor induced by harmaline in rats. N2 - BACKGROUND: Harmaline-induced tremor is a well-known model of essential tremor in humans. T1 - Apomorphine enhances harmaline-induced tremor in rats. Tremors in Parkinson's disease: Symptom analysis and

#Actimeter tremor index registration

Quantitative assessment of Parkinsonian patients by continuousĪ new approach in the assessment of motor activity inĪmbulatory monitoring of tremor and other movements before andĪfter thalamotomy: A new quantitative technique.Ī new actigraph for long-term registration of theĭuration and intensity of tremor and movement. Validity of long-term electromyography in theĪmbulatory activity monitoring: An evaluation ofĭay-to-day variability in patients with Parkinson's disease Long-term tremor recordings in Parkinsonian and essential Three-dimensional tremor measurements of the hand. Relations between trunk and limb movements and effects of circadianĬompliance, reliability, and validity of self-monitoringįor physical disturbances of Parkinson's Disease. Quantitative assessment of parkinsonian and essential tremor:Ĭlinical application of triaxial accelerometry.Ĥ5-hour continuous quintuple-site actimetry: Psychophysiological methods in monitoring and field studies (pp. Multiple physiological parameters within their behavioral andĪmbulatory assessment: Computer-assisted psychological and Towards a comprehensive technology for recording and analysis of Joint amplitude and frequency analysis of tremorĭetection of posture and motion by accelerometry: A validation Psychological and psychophysiological methods in monitoring and field (Eds.), Recent developments in Parkinson'sĪssessment of posture and motion by multichannel piezoresistive Unified Parkinson's disease rating scale. Variability in amplitude of untreated essential tremor.īaltimore: Johns Hopkins University Press Interaction by means of long-term EMG recording and Wrist tremor: Investigation of agonist-antagonist First citation in article Crossref, Google Scholar This methodology is suitable for the detection of diurnal changes in tremor activity, especially amplitude changes, and for the psychophysiological investigation of enhanced tremor caused by task demands and emotional reactions.Ģ4 hour tremor quantification based on EMG recording. The best predictions of daytime monitoring measures, based on resting measures, were made for left hand tremor. Findings indicated an increase between resting tremor and postural tremor in the three tremor parameters, an increase under distraction, and enhanced activity in sitting compared to standing/walking. Further issues included consistencies of amplitude measurements across hands, between tasks, and between segments of recordings. A repeated measurement MANOVA was used to test the effects of posture and night-day differences in tremor activity. The DC components of multi-channel accelerometry allowed the detection of posture. The tremor parameters, such as amplitude, frequency, and occurrence (percent of time), were derived by joint amplitude-frequency analysis. A total of 25 right-handed patients with Parkinson's disease were recorded in a rest condition and in a postural tremor test, and during 24-h ambulatory monitoring.

Abstract This study describes a new method, based on accelerometry, which quantifies tremor activity and posture continuously.